AMQ50 (5-Amino-1mq)

AMQ50 (5-Amino-1MQ) is a small-molecule research compound studied for its role in cellular energy regulation, fat metabolism, and mitochondrial function. Classified as a potent nicotinamide N-methyltransferase (NNMT) inhibitor, this molecule has become a focal point for research exploring links between metabolism, energy expenditure, and age-related conditions.​
Preclinical and laboratory studies highlight that 5-Amino-1MQ inhibits NNMT—an enzyme that modulates nicotinamide metabolism and affects cellular NAD⁺ levels. By blocking NNMT activity, 5-Amino-1MQ has been shown to favorably influence metabolic processes by promoting fat utilization, improving mitochondrial energy output, and supporting oxidative metabolism. This mechanism makes it valuable for research into obesity, insulin resistance, and metabolic syndrome.